The BRAF protein is a protein encoded by the BRAF gene, which is found on chromosome seven, and it plays a crucial role in cell growth by transmitting signals inside the cell, primarily promoting cell division.
Understanding the BRAF Protein
The BRAF protein is an important part of the RAS/MAPK pathway, which controls cell growth, division, and differentiation. When this pathway malfunctions, it can lead to uncontrolled cell growth and cancer.
Key Functions of BRAF Protein
- Cell Growth Regulation: BRAF helps regulate how cells grow and divide.
- Signal Transmission: It sends signals within the cell to control various cellular functions.
- Cell Division Promotion: BRAF stimulates cell division as part of its normal function.
BRAF Mutations and Cancer
Mutations in the BRAF gene can lead to the production of an altered BRAF protein that is constantly active. This can cause cells to grow and divide uncontrollably, leading to the development of various cancers, including:
- Melanoma
- Colorectal cancer
- Thyroid cancer
Therapeutic Implications
Due to its role in cancer development, BRAF is a target for cancer therapy. BRAF inhibitors are drugs designed to block the activity of the mutated BRAF protein, helping to slow or stop cancer growth.
