Yes, a person with XXY chromosomes is still considered male.
Understanding XXY Chromosomes
Usually, a female has two X chromosomes (XX), and a male has one X and one Y chromosome (XY). The presence of a Y chromosome is the key determinant of maleness. However, in Klinefelter syndrome (also known as 47,XXY), a genetic condition affecting males, an extra X chromosome is present (XXY). Despite the extra X, the presence of the Y chromosome means the individual is genetically male. Klinefelter syndrome - NHS, Klinefelter syndrome: MedlinePlus Genetics, Klinefelter Syndrome (for Parents) | Nemours KidsHealth, Klinefelter syndrome - Symptoms and causes - Mayo Clinic, Klinefelter syndrome - Wikipedia, Klinefelter syndrome Information | Mount Sinai - New York
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Key Point: The Y chromosome is responsible for initiating male development. The extra X chromosome in Klinefelter syndrome does not override this.
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Klinefelter syndrome: This condition affects only males and often goes undiagnosed. While it can cause developmental differences, it does not change the sex assigned at birth.
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Genetic Sex vs. Gender Identity: It is crucial to differentiate between genetic sex (determined by chromosomes) and gender identity (a person's internal sense of being male, female, both, or neither). Having XXY chromosomes does not determine a person's gender identity.
Individuals with Klinefelter syndrome may experience certain health challenges, but their biological sex remains male due to the presence of the Y chromosome. Rare Disorder of Sexual Differentiation with a Mosaic 46,XX/47,XXY ... states that individuals with a normal Y chromosome and multiple copies of X chromosomes, such as XXY, are still males.
