The estimated glucose disposal rate (eGDR) is calculated using a specific formula that takes into account waist circumference, hypertension status, and HbA1c levels. A higher eGDR indicates better insulin sensitivity.
Here's the formula and explanation:
eGDR Calculation
The eGDR is calculated using the following formula (as referenced):
eGDR (mg/kg/min) = 21.158 - (0.09 × waist circumference in cm) - (3.407 × hypertension, 1=yes 0=no) - (0.551 × HbA1c%)
Components of the Formula:
- 21.158: This is a constant value in the equation.
- 0.09 × waist circumference (cm): Waist circumference is a measure of abdominal obesity. A larger waist circumference is associated with lower insulin sensitivity.
- 3.407 × hypertension (1=yes, 0=no): Hypertension (high blood pressure) is a risk factor for insulin resistance. If the individual has hypertension, the value is 1; otherwise, it's 0.
- 0.551 × HbA1c (%): HbA1c is a measure of average blood glucose levels over the past 2-3 months. Higher HbA1c levels indicate poorer glucose control and reduced insulin sensitivity.
Example Calculation:
Let's say we have an individual with the following characteristics:
- Waist circumference: 90 cm
- Hypertension: No (0)
- HbA1c: 6.5%
Then, the eGDR would be calculated as follows:
eGDR = 21.158 - (0.09 90) - (3.407 0) - (0.551 * 6.5)
eGDR = 21.158 - 8.1 - 0 - 3.5815
eGDR = 9.4765 mg/kg/min
Interpretation
A higher eGDR value suggests better insulin sensitivity, meaning the body is more efficient at using glucose. Conversely, a lower eGDR suggests insulin resistance.
