Several new medicines and treatment approaches are emerging for managing uric acid levels and treating gout, a condition caused by high uric acid. Let's explore some key options:
Newer Medications for Gout Management
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Febuxostat (Uloric): This medication is a xanthine oxidase inhibitor, meaning it reduces the production of uric acid in the body. It's available in 40mg and 80mg tablets. The recommended starting dose for gout is 40mg once daily, potentially increasing to 80mg after two weeks if uric acid levels remain above 6 mg/dL. [Source: Febuxostat is available in 40-mg and 80-mg tablets. For the treatment of gout, it is recommended that the drug be started at 40 mg by mouth once daily. Two weeks after initiation, if serum uric acid levels are not below 6 mg/dL, the dose can be increased to 80 mg daily.]
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Pegloticase (KRYSTEXXA): This is a prescription medicine used in adults to reduce gout signs and symptoms not controlled by other treatments. [Source: KRYSTEXXA is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.]
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Canakinumab (Ilaris): The FDA approved this medication for treating gout flares in adults who cannot take NSAIDs (nonsteroidal anti-inflammatory drugs). [Source: The US Food and Drug Administration (FDA) has approved canakinumab (Ilaris) for the treatment of gout flares in adults who cannot be treated with NSAIDs,]
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AC 201: This IL-1β modulator, initially developed for osteoarthritis, shows promise in reducing gout flares by targeting IL-1β. [Source: AC 201 is an IL-1β modulator that was originally developed for the treatment of osteoarthritis. It not only reduces gout flares by its IL-1β...]
Understanding Treatment Approaches
It's crucial to note that treatment for high uric acid and gout often involves a combination of medication to lower uric acid levels and manage acute flares. The choice of medication will depend on individual factors, including other health conditions and potential drug interactions. Consult a healthcare professional for personalized guidance.
