In hematology, SPS typically refers to Sticky Platelet Syndrome, a rare blood disorder characterized by platelets that aggregate (clump together) more easily than normal.
Understanding Sticky Platelet Syndrome (SPS)
SPS is a thrombophilic thrombocytopathy, meaning it's a platelet disorder that predisposes individuals to blood clots (thrombophilia). It is often familial, exhibiting an autosomal dominant inheritance pattern, suggesting that only one copy of the affected gene is needed to express the condition.
Characteristics of SPS
The hallmark of SPS is increased in vitro (in a lab setting) platelet aggregation in response to low concentrations of adenosine diphosphate (ADP) and/or epinephrine (EPI). This means that when a blood sample is tested, the platelets clump together excessively when exposed to these substances, even at concentrations that wouldn't normally cause such a reaction.
Key Features Summarized
| Feature | Description |
|---|---|
| Full Name | Sticky Platelet Syndrome |
| Type | Thrombophilic thrombocytopathy (platelet disorder leading to increased clotting risk) |
| Inheritance | Often familial, autosomal dominant |
| Diagnostic Marker | Increased in vitro platelet aggregation with low concentrations of ADP and/or epinephrine (EPI) |
Clinical Significance
While SPS is identified through lab testing, its clinical implications can be significant. The increased tendency for platelets to aggregate can lead to:
- Thrombotic events: Increased risk of blood clot formation in arteries and veins, potentially leading to stroke, heart attack, or deep vein thrombosis (DVT).
- Pregnancy complications: Increased risk of miscarriage, preeclampsia, and other pregnancy-related complications due to placental thrombosis.
- Other vascular issues: Potentially contributing to migraines or other vascular problems.
Important Note
It is crucial to consult with a hematologist for accurate diagnosis and management of SPS. The information provided here is for general knowledge and does not substitute professional medical advice.
