The classic triad of Thrombotic Thrombocytopenic Purpura (TTP) consists of microangiopathic hemolytic anemia (MAHA), thrombocytopenia, and neurologic dysfunction.
Here's a breakdown of each component:
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Microangiopathic Hemolytic Anemia (MAHA): This involves the destruction of red blood cells as they pass through small blood vessels. This destruction results in anemia, characterized by low red blood cell count. The "microangiopathic" aspect refers to the damage occurring in small blood vessels.
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Thrombocytopenia: This refers to a low platelet count in the blood. Platelets are essential for blood clotting. In TTP, platelets are consumed as they aggregate in small blood vessels, leading to the decrease in their number in circulation.
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Neurologic Dysfunction: TTP can affect the brain, leading to various neurological symptoms. These symptoms can range from mild headaches and confusion to more severe manifestations such as seizures, stroke, or coma.
While this triad is considered classic, it's important to note that not all patients with TTP present with all three features. The absence of one or more components doesn't necessarily rule out the diagnosis of TTP.
