Based on the provided reference, B12, specifically when taken with folic acid, does not lower histamine. In fact, folic acid combined with vitamin B12 can potentially raise histamine levels.
Understanding the Relationship
It's important to understand how vitamins and other substances interact with histamine in the body. Histamine is a compound involved in immune responses, digestion, and neurological function. Its levels can be affected by various factors, including dietary intake and vitamin levels.
The provided reference notes that Vitamin C acts as a modulator, where decreasing plasma ascorbic acid can increase blood histamine levels. While the provided reference doesn't directly state that B12 lowers histamine, it does indicate that folic acid (with B12) can potentially raise it.
Factors Affecting Histamine Levels
Several factors can influence histamine levels in the body:
- Dietary Intake: Certain foods are naturally high in histamine or can trigger histamine release.
- Vitamin Levels: As the reference suggests, vitamins like Vitamin C can modulate histamine levels. There is indication that folic acid, especially when taken with B12, can increase them.
- Enzyme Activity: The enzymes DAO (diamine oxidase) and HNMT (histamine N-methyltransferase) break down histamine. Reduced activity of these enzymes can lead to higher histamine levels.
- Gut Health: An imbalance in gut bacteria can also affect histamine production and breakdown.
- Immune Response: Allergic reactions and other immune responses can trigger histamine release.
Caution and Further Research
The relationship between vitamins, histamine, and overall health is complex and requires further research. It's crucial to consult with a healthcare professional before making significant dietary changes or taking supplements, especially if you have histamine intolerance or related conditions.
