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Does hCG Work Immediately?

Published in Hormone Action 2 mins read

No, hCG does not work immediately.

Understanding hCG's Onset

Human chorionic gonadotropin (hCG) is a hormone that mimics the action of luteinizing hormone (LH) in the body. While both hormones trigger similar responses, they differ significantly in their half-lives.


Hormone Half-life Peak Onset
LH 30 minutes Rapid
hCG 30 hours 72-96 hours


As shown in the table, LH has a very short half-life, meaning its effects occur rapidly. On the other hand, hCG has a much longer half-life of 30 hours. This longer half-life influences how quickly the hormone starts to have an effect.

Why is hCG not immediate?

Due to its extended half-life, the peak effect of increased testosterone from hCG is observed around 72-96 hours after administration. Here is a breakdown:

  • Extended Half-Life: hCG remains active in the body for a longer period compared to LH.
  • Delayed Response: It takes time for the body to process the hCG and produce the desired hormonal response.

Practical Implications

For example, when hCG is used to stimulate testosterone production, one should not expect an immediate change. The peak effect, as stated in the reference, occurs much later, between 72 and 96 hours after administration.


Therefore, while hCG is effective, its action is not immediate, and patience is essential when undergoing treatment with this hormone.

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