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What Drugs Cause Low Testosterone?

Published in Hormone Health 2 mins read

Several types of medications can potentially lower testosterone levels. This can be a side effect to be aware of, especially for men concerned about their hormone health.

Medications Associated with Lowering Testosterone

The following categories of drugs have been linked to decreased testosterone production:

  • Statins: Commonly prescribed to lower cholesterol, some studies suggest statins can impact testosterone levels.

  • Antidepressants: Certain antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs), may affect testosterone production.

  • Chemotherapeutics: Chemotherapy drugs, used to treat cancer, often have significant effects on hormone levels, including testosterone.

  • Opioids: Opioid pain medications can interfere with the hypothalamic-pituitary-gonadal axis, which regulates testosterone production. Long-term use is more likely to cause a significant decrease.

  • Antifungals: Some antifungal medications, especially ketoconazole, can inhibit testosterone synthesis.

  • Hypertension Medications: Certain medications used to treat high blood pressure, such as spironolactone and thiazide diuretics, can impact testosterone.

It's important to note that the extent of the effect on testosterone levels can vary depending on the specific drug, dosage, duration of use, and individual factors. If you are concerned about low testosterone levels, you should consult with your healthcare provider to discuss your medications and potential alternative options. They can conduct appropriate testing to determine your testosterone levels and recommend the best course of action.

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