Yes, human chorionic gonadotropin (hCG) can increase testicle size. hCG stimulates the testicles to produce testosterone, leading to increased testicular volume. Multiple studies support this.
Evidence from Research
Several studies demonstrate a significant increase in testicular volume following hCG treatment:
- Study 1: One study showed a mean testicular volume increase from 5.45 cc to 6.83 cc on the left side and 5.53 cc to 7.03 cc on the right side after hCG treatment (p<0.005). [Source needed - The provided text only mentions this result without a specific source.]
- Study 2: Another study reported a mean testicular volume increase from 5.5 ± 1.1 mL to 10.8 ± 1.6 mL during hCG treatment (P < 10-6). [Source: Gonadotropin therapy in men with isolated hypogonadotropic ...]
- Study 3: Research indicates that hCG treatment increases serum testosterone levels, penile length, and testicular volume in patients with hypogonadotropic hypogonadism (IHH). [Source: Penile Growth in Response to Human Chorionic Gonadotropin (hCG)...]
- Study 4: An open-label clinical trial demonstrated a significant increase in testicular volume with the combined use of corifollitropin alfa and hCG over 52 weeks. [Source: An open-label clinical trial to investigate the efficacy and safety of ...]
It's important to note that the rate at which testicular size increases with hCG varies between individuals. [Source: Targeting Micropenis, Supporting Fertility, and Increasing] The optimal hCG dosage for maximizing testicular stimulation is generally considered to be between 6000 and 10,000 IU. [Source: Testicular responses to hCG stimulation at varying doses in men...]
While hCG can increase testicle size, it's crucial to remember that this effect is a consequence of increased testosterone production and not a direct result of hCG acting on testicular tissue independently. HCG's primary role is to stimulate the testicles to produce their own testosterone. [Sources: Several sources indirectly support this through the demonstrated increase in testosterone levels following hCG administration.] In cases where testicular shrinkage is a side effect of testosterone replacement therapy (TRT), hCG can be used to help maintain testicular size and function. [Source: How to Reverse the Main Side Effect of TRT]
