Mast cells are immune cells crucial for the body's defense system. They originate in the bone marrow and then travel to and reside in various tissues throughout the body.
Development and Location
Mast cells belong to the myeloid lineage of immune cells. Their development begins in the bone marrow. Precursor cells, or progenitor cells, then circulate in the bloodstream before settling in different tissues. The maturation process into a fully functional mast cell is influenced by stem cell factors produced by other cells within the tissue where they reside. This localized influence ensures that mast cells are appropriately distributed and adapted to their specific tissue environment.
Function
While their exact roles are still being researched, mast cells are known to play a vital role in:
- Immune Responses: They are key players in both allergic reactions and defense against parasites.
- Wound Healing: They contribute to the repair process following tissue damage.
While not explicitly detailed in the provided reference, it is important to note that mast cells are known to release histamine and other inflammatory mediators upon activation. This release is crucial in both beneficial immune responses and, in cases of allergy, can contribute to the symptoms experienced by individuals.
