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What is the difference between the Immune System and an Autoimmune Disorder?

Published in Immune System Autoimmunity 3 mins read

The key difference is simple: The immune system is the body's natural defense network, while an autoimmune disorder is a condition where this defense system malfunctions and attacks the body itself. There isn't a separate "autoimmune system"; it's the immune system acting incorrectly.

The Immune System: Your Body's Defender

Your immune system is a complex network of cells, tissues, and organs that work together to protect you from harmful invaders like bacteria, viruses, fungi, and parasites. Its primary job is to identify foreign substances (called antigens) and eliminate them.

  • Normal Function: It recognizes threats and mounts a targeted response.
  • How it Works (in part): The immune system produces antibodies against these antigens that enable it to destroy these harmful substances. This is a crucial part of keeping you healthy.

Think of it like your body's security system, constantly patrolling and neutralizing threats from the outside world.

Understanding Autoimmune Disorders: When the System Goes Awry

In an autoimmune disorder, the immune system loses its ability to distinguish between foreign invaders and your own healthy cells and tissues. It mistakenly identifies parts of your own body as harmful antigens.

  • The Dysfunction: When you have an autoimmune disorder, your immune system does not distinguish between healthy tissue and potentially harmful antigens.
  • The Result: As a result, your body sets off a reaction that destroys normal tissues.

Instead of attacking external threats, the immune system turns inward, attacking healthy organs, joints, skin, or other parts of the body. Examples include Type 1 Diabetes, Rheumatoid Arthritis, Lupus, and Multiple Sclerosis.

Key Distinction: Function vs. Dysfunction

To summarize the core difference:

Feature Immune System (Normal) Autoimmune Disorder (Dysfunction)
Role Defends the body against external threats Attacks the body's own healthy tissues
Target Antigens from pathogens (viruses, bacteria) Antigens from the body's own tissues (self)
Self-Recognition Distinguishes self from non-self Fails to distinguish self from non-self
Outcome Protects health Damages healthy tissues and causes disease

An autoimmune disorder is essentially the immune system malfunctioning, not a separate system itself. The immune system is the entity; autoimmunity is a state of its dysfunction.

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