Based on the provided information, Natural Killer (NK) cells can be derived from umbilical cord blood.
Umbilical Cord Blood: A Source for NK Cells
The reference specifically notes the use of umbilical cord blood as a source material for obtaining NK cells. This is particularly relevant in the context of developing advanced cell-based therapies.
- Origin Point: NK cells can be derived from umbilical cord blood.
- Application in Therapy: NK cells sourced from umbilical cord blood have been utilized to create specialized therapeutic cells, such as CAR. CD19 NK cells.
- Engineered Capabilities: These derived cells can be modified to self-produce important signaling molecules like the cytokine IL-15.
- Self-production of IL-15 enhances their functionality through autocrine (acting on themselves) and paracrine (acting on nearby cells) mechanisms.
- This cytokine production also helps improve their longevity and presence in the body (persistence in vivo).
The use of umbilical cord blood as a source highlights its potential in generating NK cells for various applications, including innovative immunotherapies.
