Low IgA, or IgA deficiency, is primarily caused by genetics or, in rare cases, by certain medications.
Here's a more detailed breakdown:
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Genetic Factors: In about 1 in 5 cases, IgA deficiency is inherited. This means the condition is passed down through families. While the exact genes responsible are not fully understood, a family history of IgA deficiency increases the likelihood of an individual developing the condition.
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Medications: Certain medications can sometimes lead to decreased IgA levels. The specific drugs that can cause this are rare, and the mechanism by which they lower IgA is not always well-defined.
It's important to note that in many cases of IgA deficiency, the cause remains unknown (idiopathic).
