The primary cells that produce interleukins are CD4 helper T-lymphocytes, but monocytes, macrophages, and endothelial cells also contribute to their production.
Here's a breakdown:
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CD4+ Helper T Cells: These cells are arguably the most significant producers of interleukins. They play a crucial role in orchestrating the immune response by secreting various interleukins that influence the activity of other immune cells, including B cells and cytotoxic T cells.
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Monocytes and Macrophages: These are phagocytic cells that are part of the innate immune system. They produce interleukins, particularly in response to pathogens or inflammatory signals. These interleukins help to recruit other immune cells to the site of infection or inflammation.
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Endothelial Cells: These cells line the blood vessels and also contribute to interleukin production, especially during inflammation. The interleukins produced by endothelial cells can help to increase vascular permeability and facilitate the migration of immune cells into tissues.
In summary, while CD4+ helper T cells are the main producers, interleukins are produced by a variety of immune cells, and even by non-immune cells like endothelial cells, depending on the context and stimulus. These molecules are vital for communication and regulation within the immune system.
