Age-associated B cells (ABCs) are a specialized type of memory B cell that arise under inflammatory conditions and express the transcription factor T-bet. They are thought to contribute to autoimmunity, particularly in diseases like Systemic Lupus Erythematosus (SLE), by acting as a source of autoantibody-secreting cells.
Key Characteristics of ABCs:
- Formation: Develop in the presence of inflammation.
- Classification: Considered a subset of memory B cells.
- Transcription Factor: Express the T-bet transcription factor.
- Role in Disease: Associated with disease activity, particularly in autoimmune disorders like SLE.
- Function: Thought to be a source of autoantibody-secreting cells, contributing to the development of autoimmunity.
In summary, ABCs are memory B cells that appear during inflammation, express T-bet, and are implicated in autoimmune diseases by producing autoantibodies.
