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What Causes CPE?

Published in Infection Causes 2 mins read

CPE, or Carbapenemase-Producing Enterobacterales, infections are primarily caused by specific medical procedures and treatments that can introduce these bacteria into the body.

Common Causes of CPE Infections

CPE infections often occur in healthcare settings. The following are significant factors contributing to the spread and development of CPE:

  • Major Surgery: Post-operative settings can increase susceptibility to CPE infections.
  • Medical Devices: The use of medical devices like catheters or IV lines provides a potential entry point for CPE.
    • Example: A urinary catheter, if not handled correctly, can introduce bacteria leading to infection.
  • Cancer Treatment: Patients undergoing cancer treatment often have weakened immune systems, making them more vulnerable to CPE.
  • Intensive Care Unit (ICU) or Transplant Ward Treatment: These environments often host patients with compromised health, increasing the risk of CPE infection.


Summary of Causes

Cause Description
Major Surgery Surgical procedures create openings for bacteria to enter the body.
Medical Device Insertion Devices such as catheters and IV lines provide a direct pathway for bacteria.
Cancer Treatment Immunocompromised patients are more susceptible to various infections, including CPE.
ICU or Transplant Ward Stay High-risk environments due to the concentration of patients with weakened immune systems and invasive procedures.


In essence, the primary causes of CPE infections revolve around situations where the body's defenses are lowered and/or medical procedures provide direct access for bacteria. Understanding these causes can help prevent and control the spread of CPE infections.

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