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Is High CRP Normal in CBC?

Published in Inflammation Markers 2 mins read

No, a high CRP (C-reactive protein) is generally not normal in a Complete Blood Count (CBC). CRP is a marker of inflammation in the body and is often measured separately from a CBC.

Here's a more detailed explanation:

  • What is CRP? CRP is a protein produced by the liver in response to inflammation. Its level in the blood rises when there's inflammation somewhere in the body.

  • What is a CBC? A Complete Blood Count measures different components of your blood, including red blood cells, white blood cells, and platelets. It primarily helps evaluate overall health and detect a wide range of disorders, such as anemia, infection, and certain cancers.

  • Why are they usually separate tests? While a CBC can detect signs of infection or inflammation by looking at elevated white blood cell counts, CRP is a more specific and sensitive marker for inflammation. Therefore, if a doctor suspects inflammation, they are likely to order a CRP test in addition to or instead of relying solely on the CBC.

  • Normal CRP Levels:

    • Generally, a CRP level less than 3 mg/L is considered normal.
    • Values above this indicate some degree of inflammation.
  • Elevated CRP Levels:

    • 3-10 mg/L: May indicate low-grade inflammation, often associated with conditions like obesity, metabolic syndrome, or smoking.
    • 10-100 mg/L: Suggests more significant inflammation, potentially due to infections, autoimmune diseases, or injuries.
    • Above 100 mg/L: Usually indicates a severe infection, vasculitis, or major trauma.
  • When might CRP be ordered with a CBC? A doctor might order both a CBC and CRP if they suspect an infection or inflammatory condition. The CBC can provide information about the overall blood cell counts, while the CRP helps confirm the presence and severity of inflammation.

In summary, while a CBC can offer clues related to inflammation, a CRP test is the specific and sensitive measure used to determine the presence and extent of inflammatory processes within the body. Therefore, a high CRP level is not considered normal.

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