Keratinocytes, the primary cells of the epidermis, produce various chemicals involved in skin function. Based on the provided reference, two types of chemicals they produce include:
Eicosanoids
- Eicosanoids are a group of signaling molecules made by the oxidation of fatty acids.
- They include prostaglandins, thromboxanes, and leukotrienes.
- They have diverse roles in inflammation, immunity, and other cellular processes.
- For example, they play a crucial part in the inflammatory response within the skin.
Neuropeptides
- Neuropeptides are small protein-like molecules used by neurons to communicate with each other.
- Keratinocytes also produce neuropeptides.
- Examples given in the reference are:
- Propiomelanocortin
- α MSH (alpha-Melanocyte Stimulating Hormone)
- These neuropeptides play a role in skin physiology, such as in pigmentation and the skin's response to stress.
| Chemical Type | Examples | Function in Skin |
|---|---|---|
| Eicosanoids | Prostaglandin (PG) E2 | Involved in inflammation, immune response, wound healing. |
| Neuropeptides | Propiomelanocortin, α MSH | Participates in functions such as pigmentation and the response to stress. |
Therefore, based on the reference, keratinocytes produce eicosanoids, particularly prostaglandin E2, and neuropeptides, such as propiomelanocortin and α MSH.
