The following medications can help improve GFR (Glomerular Filtration Rate), particularly in the context of chronic kidney disease:
Medications for Improving GFR
| Class/medicines | Specific Medications | GFR Considerations |
|---|---|---|
| SGLT2 inhibitors | dapagliflozin, empagliflozin, ertugliflozin | - Starting treatment is not recommended if GFR is < 25. - Continuing treatment is acceptable if GFR decreases to < 25. |
| GLP-1 receptor agonists | dulaglutide | - Not recommended if GFR is < 15. |
Understanding GFR and its Importance
Glomerular Filtration Rate (GFR) measures how well your kidneys are filtering waste from your blood. A lower GFR indicates reduced kidney function. Certain medications can help improve or slow the decline of GFR, especially in chronic kidney disease (CKD).
SGLT2 Inhibitors
These medications, including dapagliflozin, empagliflozin, and ertugliflozin, work by increasing the excretion of glucose through the urine, which has been shown to have a protective effect on the kidneys and can help in improving GFR.
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Dapagliflozin: It's important to note that while starting treatment isn't recommended if your GFR is below 25, it is still acceptable to continue treatment if your GFR drops to that level while on the medication.
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Empagliflozin
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Ertugliflozin
GLP-1 Receptor Agonists
- Dulaglutide: This medication is generally not recommended for use if GFR is below 15.
Important Considerations:
- It's crucial to work with your healthcare provider to determine the most appropriate medication for your specific situation.
- GFR levels need to be monitored regularly to ensure the safety and effectiveness of the chosen treatment.
- Medication usage should be adjusted as required according to kidney function.
In summary, SGLT2 inhibitors like dapagliflozin, empagliflozin, ertugliflozin and GLP-1 receptor agonists like dulaglutide can be prescribed to improve GFR, with specific GFR considerations for initiating and continuing treatment.
