The major proteins involved in lipolysis within adipocytes are Adipose Triglyceride Lipase (ATGL) and Hormone-Sensitive Lipase (HSL), alongside Peri A.
Key Proteins in Lipolysis
Lipolysis is the process of breaking down triglycerides (fats) into glycerol and fatty acids. This process is crucial for energy metabolism. Here's a breakdown of the key proteins involved:
- Adipose Triglyceride Lipase (ATGL): ATGL initiates lipolysis by removing the first fatty acid from triacylglycerol, creating diacylglycerol. It is a rate-determining enzyme.
- Hormone-Sensitive Lipase (HSL): HSL hydrolyzes diacylglycerol to monoacylglycerol. It is also a rate-determining enzyme.
- Peri A: Peri A regulates lipid storage and release in the adipocyte.
Role in Lipid Storage and Release
These proteins play a vital role in regulating how fat is stored and released in the body's fat cells (adipocytes). ATGL and HSL are major rate-determining enzymes for lipolysis in adipocytes. Peri A, ATGL and HSL regulate lipid storage and release in the adipocyte.
Here's a summary table:
| Protein | Function | Role in Lipolysis |
|---|---|---|
| Adipose Triglyceride Lipase (ATGL) | Hydrolyzes triacylglycerol to diacylglycerol | Initiates lipolysis |
| Hormone-Sensitive Lipase (HSL) | Hydrolyzes diacylglycerol to monoacylglycerol | Further breaks down fats |
| Peri A | Regulates lipid storage and release in adipocytes | Regulates lipid storage and release |
