While multiple factors can contribute to liver disease, deficiencies in certain vitamins, specifically vitamin A and D, are strongly implicated. A recent study highlights the significant role of vitamin A deficiency in the development and progression of liver disease.
Vitamin A and Liver Disease
According to research [148], a high prevalence of vitamin A deficiency exists in patients with advanced liver disease. Furthermore, vitamin A levels are strongly correlated with several indicators of liver dysfunction, including:
- Liver dysfunction: Lower vitamin A levels are associated with impaired liver function.
- Portal hypertension: Vitamin A deficiency is linked to increased pressure in the portal vein, a major vessel carrying blood to the liver.
- Bile acid levels: Disrupted vitamin A levels correlate with imbalances in bile acid production and regulation.
Vitamin D and Liver Disease
The same study also indicated that vitamin D deficiencies are common in individuals with advanced liver disease [148]. While the exact mechanisms are still being investigated, vitamin D is known to play a role in inflammation and immune regulation, both of which can impact liver health.
In Summary
Although several vitamins and minerals are essential for overall health, vitamin A and vitamin D deficiencies are particularly relevant in the context of liver disease, and Vitamin A deficiency is associated with several indicators of liver dysfunction [148]. Addressing these deficiencies may be a crucial part of managing and potentially mitigating the progression of liver conditions.
