Lupus is not caused by a single organ. Instead, it arises from problems within the immune system.
While no single organ is the cause of lupus, the kidneys are frequently affected by the disease. According to the provided reference, about half of people with lupus experience kidney involvement, making the kidney the most extensively studied organ in the context of lupus. The immune system malfunctions in lupus, leading to inflammation and damage in various parts of the body, including the kidneys.
