Comparing small and large lymphocytes reveals distinctions primarily related to their activity level and morphology, as described in the provided reference.
The primary difference between small and large lymphocytes lies in their activity state, size, and cytoplasm content. Small lymphocytes are typically inactive, while large lymphocytes are active forms of these immune cells.
Small Lymphocytes
Based on the reference, small lymphocytes are inactive. They represent the majority of lymphocytes circulating in the blood and residing in lymphoid organs. They are generally smaller in size compared to large lymphocytes.
Large Lymphocytes
According to the reference:
- Large lymphocytes (10 - 15 microns) are larger than small lymphocytes.
- They contain more cytoplasm than small lymphocytes.
- The cytoplasm remains basophilic.
- Large lymphocytes are active B or T cells.
These characteristics indicate that large lymphocytes are typically small lymphocytes that have been activated, often by exposure to an antigen, leading to increased size and metabolic activity.
Key Differences Summarized
Here is a comparison based on the provided reference:
| Feature | Small Lymphocytes | Large Lymphocytes |
|---|---|---|
| Activity | Inactive | Active B or T cells |
| Size | Smaller | Larger (10 - 15 microns) |
| Cytoplasm | Less cytoplasm | More cytoplasm |
| Cytoplasm Staining | (Not specified in reference) | Basophilic |
It is important to note that it is not possible to distinguish B- and T-lymphocytes based solely on their size or appearance (morphology) at this level of magnification; both B and T cells can appear as small, inactive lymphocytes or enlarge into active large lymphocytes upon stimulation.
