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What is the pH of lysosomes?

Published in Lysosome pH 1 min read

The pH of lysosomes is highly acidic, typically ranging from 4.5 to 5.0.

Lysosomes are crucial organelles within cells responsible for waste disposal and recycling. To efficiently perform these functions, they maintain a highly acidic internal environment. This acidity is essential for the activity of the hydrolytic enzymes housed within lysosomes, which degrade various biomolecules.

Why is the pH of lysosomes important?

  • Enzyme Activity: The acidic pH allows the hydrolytic enzymes to function optimally. These enzymes break down proteins, lipids, carbohydrates, and nucleic acids.
  • Cellular Homeostasis: By maintaining a low pH, lysosomes contribute to cellular homeostasis by degrading damaged or unwanted cellular components.
  • Degradation of Biomolecules: The acidic environment facilitates the breakdown of engulfed biomolecules.

As stated in the provided reference, lysosomes generate a highly acidic environment of pH 4.5 – 5.0 and house hydrolytic enzymes that degrade engulfed biomolecules, contributing to cellular homeostasis.

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