The neoplastic cells of MALT lymphoma, a type of B-cell lymphoma, typically express specific CD markers, helping in their diagnosis. These markers can be grouped into those that are usually positive and those that are usually negative.
Commonly Expressed CD Markers in MALToma
According to the reference, the following CD markers are commonly positive in MALToma:
- CD19: A pan-B-cell marker.
- CD20: Another pan-B-cell marker.
- CD79a: A component of the B-cell receptor.
- PAX5: A B-cell lineage-specific transcription factor.
- Bcl-2: An anti-apoptotic protein.
These markers are essential for identifying MALToma cells as B-cell in origin.
CD Markers Usually Negative in MALToma
The reference also indicates that MALToma cells typically lack expression of the following markers:
- CD5: While most MALTomas are CD5 negative, infrequent cases can be positive, which may be associated with a more aggressive clinical course.
- CD10: A marker associated with germinal center B-cells.
- Bcl-1: Also known as cyclin D1; not usually present in MALTomas.
- CD23: Another marker not usually expressed by MALToma cells.
The lack of these markers helps to distinguish MALToma from other types of lymphomas.
CD43 Expression in MALToma
- The reference mentions that CD43 expression in MALToma can be either positive or negative, meaning it is a variable marker in this disease.
Summary of CD Markers in MALToma
| CD Marker | Expression in MALToma |
|---|---|
| CD19 | Positive |
| CD20 | Positive |
| CD79a | Positive |
| PAX5 | Positive |
| Bcl-2 | Positive |
| CD43 | Positive or Negative |
| CD5 | Usually Negative (rarely positive) |
| CD10 | Negative |
| Bcl-1 | Negative |
| CD23 | Negative |
Key takeaway: The characteristic profile of CD markers, particularly the positive expression of CD19, CD20, CD79a, PAX5, and Bcl-2 alongside the lack of CD10, Bcl-1, and CD23 expression is vital for diagnosing MALT lymphoma. The variable expression of CD43 and rare CD5 positivity highlight the need for careful evaluation.
