Grade 1 Cytokine Release Syndrome (CRS) is defined as a fever equal to or greater than 38°C.
In the context of immunotherapies like CAR T-cell therapy, CRS is a systemic inflammatory response that can occur as a result of immune cell activation. It's graded based on severity, and understanding the grading system is critical for appropriate management.
Here's a breakdown of Grade 1 CRS:
- Fever: The primary characteristic of Grade 1 CRS is a temperature of 38°C (100.4°F) or higher.
Generally, management of Grade 1 CRS focuses on supportive care. This may include:
- Monitoring: Close observation of the patient's temperature and other vital signs.
- Antipyretics: Administration of medications like acetaminophen or ibuprofen to reduce fever.
- Fluid management: Ensuring adequate hydration.
It's important to note that CRS grading can be dynamic, and patients may progress to higher grades requiring more intensive interventions. Therefore, continuous monitoring is essential.
