A ROCA score is derived from a blood test that helps determine a woman's risk of having ovarian cancer. It's specifically intended for women over 35 who have a BRCA1 or BRCA2 gene mutation, putting them at high risk for developing this type of cancer. The test itself measures the levels of CA-125, a protein often elevated in women with ovarian cancer, over time. The algorithm uses this data to estimate individual risk.
In more detail:
- ROCA Test: Stands for Risk of Ovarian Cancer Algorithm test.
- Purpose: To assess the likelihood of a woman with a high genetic risk developing ovarian cancer.
- Target Population: Women over 35 with BRCA1 or BRCA2 mutations.
- Method: Measures CA-125 levels in blood samples at regular intervals.
- Algorithm: An algorithm then analyzes these CA-125 levels and their rate of change over time to generate a risk score. A significant increase in CA-125 may indicate a higher risk, prompting further investigation by a medical professional.
- Important Note: The ROCA test is not a diagnostic test. A high ROCA score does not definitively mean a woman has ovarian cancer, but it signals the need for further evaluation and monitoring, such as transvaginal ultrasounds and other diagnostic tests.
While the ROCA test can be a valuable tool for women at high risk of ovarian cancer, it is crucial to consult with a medical professional to understand the test's limitations and interpret the results accurately within an individual's medical context.
