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Is myoglobin positive or negative?

Published in Medical Tests 2 mins read

Myoglobin is typically negative in a normal urine sample.

Understanding Myoglobin and Urine Tests

Myoglobin is a protein found in muscle tissue. When muscles are damaged, myoglobin is released into the bloodstream. The kidneys then filter myoglobin into the urine. A urine test for myoglobin can help detect muscle damage.

Interpreting Myoglobin Test Results

The presence of myoglobin in urine is abnormal. A normal urine sample should not contain myoglobin, and this is often reported as a negative result. Here's a breakdown:

  • Negative Result: A negative result means no myoglobin was detected in the urine sample, indicating no significant muscle damage. This is the expected finding in a healthy individual.
  • Positive Result: A positive myoglobin result suggests that muscle damage has occurred. This could be due to various factors, including:
    • Rhabdomyolysis (breakdown of muscle tissue)
    • Trauma or injury
    • Intense exercise
    • Certain medical conditions

Key Points from the Reference

According to the reference:

"A normal urine sample does not have myoglobin. A normal result is sometimes reported as negative."

This confirms that the absence of myoglobin is considered normal and is reported as negative. Therefore, it's important to understand that a negative test result indicates the absence of myoglobin in the urine.

Laboratory Variations

It is important to note that "Normal value ranges may vary slightly among different laboratories." Always consult with your healthcare provider for a complete interpretation of your specific results.

Result Interpretation
Negative Myoglobin is absent in urine, indicating normal results.
Positive Myoglobin is present, suggesting potential muscle damage.

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