Individuals with a history of severe allergic reactions to cephalosporin antibiotics, such as Omnicef or Keflex, should avoid ceftriaxone. This is a crucial precaution due to the risk of a potentially life-threatening allergic response. Additionally, infants younger than 28 days old receiving or expected to receive intravenous calcium should avoid ceftriaxone due to the risk of precipitation. Patients with hyperbilirubinemia (high bilirubin levels) should also avoid ceftriaxone as it may displace bilirubin from albumin, potentially leading to kernicterus. Finally, alcohol should be avoided while taking certain cephalosporins, including ceftriaxone, because of the risk of disulfiram-like reactions.
Specific Groups to Avoid Ceftriaxone:
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Individuals with severe cephalosporin allergy: A history of severe allergic reactions (anaphylaxis) to any cephalosporin antibiotic necessitates avoiding ceftriaxone. This is due to the high risk of cross-reactivity.
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Neonates (<28 days old) receiving IV calcium: Ceftriaxone and calcium can precipitate when mixed, potentially causing serious complications in neonates. Therefore, it is crucial to avoid concomitant administration in this age group.
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Patients with hyperbilirubinemia: Ceftriaxone can displace bilirubin from albumin, increasing the risk of kernicterus, especially in newborns.
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Patients consuming alcohol: Concurrent use with certain cephalosporins, including ceftriaxone, can lead to disulfiram-like reactions (alcohol intolerance), characterized by unpleasant side effects.
Important Note:
Always consult a doctor before using ceftriaxone, especially in children. The dosage should always be prescribed and supervised by a healthcare professional. This information is for general knowledge and does not substitute for professional medical advice.
