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When Should I Stop Ceftriaxone?

Published in Medication Discontinuation 2 mins read

You should stop taking ceftriaxone if you experience specific adverse reactions, as detailed below:

Ceftriaxone Discontinuation Guidelines

According to the provided reference, you should stop taking ceftriaxone if any of the following occur:

  • Seizure Activity: If you experience signs indicating a seizure is happening or could happen. This may include:
    • Uncontrollable jerking movements.
    • Loss of consciousness.
    • Confusion or altered mental state.
  • Antibiotic-Associated Diarrhea: If you develop diarrhea that is linked to antibiotic use. This could be a symptom of an underlying issue such as C. difficile infection.
  • Clostridioides difficile (C. difficile) Overgrowth: If you are diagnosed with an overgrowth of the bacteria Clostridioides difficile. This infection can cause severe diarrhea, abdominal pain, and fever.


Condition Signs & Symptoms Action
Seizure Activity Jerking, loss of consciousness, altered mental state Stop Ceftriaxone
Antibiotic-Associated Diarrhea Watery stools, abdominal cramps Stop Ceftriaxone
Clostridioides difficile Overgrowth Severe diarrhea, abdominal pain, fever Stop Ceftriaxone


It is crucial to immediately contact your healthcare provider if you suspect any of these conditions. Do not stop taking ceftriaxone without first consulting with your doctor. They will evaluate your situation and determine the appropriate course of action, which may include discontinuing ceftriaxone and potentially starting a different medication.

Remember, completing the full course of antibiotics is important unless you are advised otherwise by your physician. Stopping prematurely can lead to the infection recurring and becoming antibiotic-resistant.

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