Yes, proton pump inhibitors (PPIs) can potentially affect sleep.
PPIs, commonly used to reduce stomach acid production, have been shown to have effects on the central nervous system. This influence on the central nervous system may interfere with sleep signals within the brainstem. This is because the brainstem plays a critical role in regulating sleep-wake cycles.
While more research is needed to fully understand the extent of this impact, the potential for PPIs to disrupt sleep should be considered, especially for individuals already experiencing sleep difficulties.