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What is Lipolysis?

Published in Metabolism 2 mins read

Lipolysis is the process where your body breaks down stored fat (triglycerides) into glycerol and free fatty acids (FFAs). This breakdown is achieved through hydrolysis, where water molecules are used to split the bonds in the fat molecules.

Lipolysis is a crucial metabolic process that serves several purposes:

  • Energy Production: Free fatty acids released from lipolysis can be used as fuel by various tissues, especially during periods of fasting or intense exercise.
  • Heat Generation: Lipolysis contributes to heat production, which is essential for maintaining body temperature.
  • Insulation: Stored fat provides insulation, protecting the body from cold temperatures.

Lipolysis is a tightly regulated process influenced by several factors, including:

  • Hormones: Hormones like adrenaline, glucagon, and growth hormone stimulate lipolysis.
  • Insulin: Insulin, on the other hand, inhibits lipolysis, promoting fat storage.
  • Exercise: Exercise can increase lipolysis, mobilizing fat for energy use.
  • Diet: A low-carbohydrate diet can also stimulate lipolysis.

Beyond its natural role in the body, lipolysis is also used in various medical and cosmetic procedures. These include:

  • Injection Lipolysis: This procedure utilizes injections of substances like deoxycholic acid to chemically reduce the number of fat cells in specific areas. A well-known example is Kybella.
  • Laser Lipolysis: Laser lipolysis involves using laser energy to heat and destroy fat cells. This procedure is considered less invasive and can be used for localized fat reduction.

Lipolysis plays a vital role in energy metabolism and body fat regulation. It's a complex process influenced by various factors, including hormones, diet, and exercise. Understanding lipolysis is essential for understanding how the body manages energy storage and utilization.

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