The latest treatments for migraines include both nasal sprays and oral medications that target the CGRP pathway.
Specifically, Zavzpret (zavegepant) nasal spray represents the newest option for the acute treatment of migraine. Additionally, Nurtec ODT (rimegepant) and Ubrelvy (ubrogepant) are recent oral medications, specifically CGRP receptor antagonists (gepants), used for acute migraine treatment.
Here's a breakdown:
- Zavzpret (zavegepant) Nasal Spray: This is a calcitonin gene-related peptide (CGRP) receptor antagonist administered as a nasal spray. It's designed for rapid absorption and potentially quicker relief for some individuals.
- Nurtec ODT (rimegepant): An orally disintegrating tablet that is also a CGRP receptor antagonist. It can be used for both acute treatment and preventative treatment of migraine, which is unique among the gepants.
- Ubrelvy (ubrogepant): An oral tablet that functions as a CGRP receptor antagonist. It is indicated for the acute treatment of migraine with or without aura.
How These Medications Work:
These newer medications target the calcitonin gene-related peptide (CGRP), a molecule implicated in the development of migraine. By blocking CGRP or its receptor, these medications can help reduce or eliminate migraine pain and associated symptoms.
Important Considerations:
- It's crucial to consult with a healthcare professional to determine the most appropriate treatment plan based on individual needs, medical history, and potential drug interactions.
- Effectiveness can vary from person to person.
- These medications are generally well-tolerated, but side effects can occur. Discuss potential side effects with your doctor.
