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What is the difference between hypertrophy and atrophy?

Published in Muscle Physiology 2 mins read

The fundamental difference between hypertrophy and atrophy lies in their opposing effects on muscle mass: hypertrophy involves an increase in muscle mass, while atrophy involves a decrease in muscle mass.

Muscle Hypertrophy

Muscle hypertrophy is the enlargement of skeletal muscle fibers in response to stimuli like strength training. According to the provided reference, muscle hypertrophy occurs because "your muscle fibers get bigger or thicken," resulting from "an increase in the volume of your muscle cells."

Characteristics of Hypertrophy:

  • Increase in Muscle Size: The primary characteristic.
  • Increased Strength: Often accompanies muscle growth.
  • Improved Muscle Endurance: Can result from certain types of hypertrophy training.

Muscle Atrophy

Muscle atrophy, conversely, is the wasting or loss of muscle tissue. The reference clearly states that "muscle atrophy is a loss of muscle mass." This can happen due to various factors, including disuse, aging, malnutrition, and certain diseases.

Characteristics of Atrophy:

  • Decrease in Muscle Size: The primary characteristic.
  • Weakness: Loss of muscle strength.
  • Reduced Endurance: Decreased ability to perform physical activities.

Key Differences Summarized

Feature Hypertrophy Atrophy
Definition Increase in muscle mass Loss of muscle mass
Muscle Fibers Get bigger or thicken Shrink in size
Cause Stimuli such as strength training Disuse, aging, malnutrition, diseases
Effect Increased muscle size and often strength Decreased muscle size and often strength

In essence, hypertrophy represents muscle growth, while atrophy represents muscle loss. One is desirable for athletes and individuals seeking to improve their physical condition, while the other is generally undesirable and often a sign of underlying health issues or inactivity.

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