Yes, Rome was attacked by Muslims, although not conquered.
The 846 Raid on Rome
In 846, Muslim raiders attacked the outskirts of Rome. This wasn't a full-scale siege, but a significant raid. The raiders, a fleet from North Africa, successfully plundered the suburbs and famously sacked two significant basilicas: Old St. Peter's and St. Paul's Outside-the-Walls. However, they were ultimately prevented from entering the city itself thanks to the strong defenses provided by the Aurelian Walls. This event demonstrates that while Rome wasn't conquered, it did experience direct Muslim military action.
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Key takeaway: The 846 raid highlights that while the Muslim forces didn't breach the city's defenses, the attack demonstrates a significant instance of direct military conflict between the Muslim forces and Rome. This was a direct assault, not simply a border skirmish or minor raid.
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Historical Significance: This event stands as a notable example of the reach of the Muslim forces during that period and the vulnerability of even a powerful city like Rome to raids. The damage to the significant religious sites underscores the event's impact.