The first line of treatment for nerve pain (neuropathic pain) typically involves medications such as antidepressants and anticonvulsants.
Understanding First-Line Treatments
According to the provided reference, the initial approach to managing neuropathic pain includes specific types of medications. These medications are chosen for their effectiveness and relatively manageable side effect profiles.
- First-line drugs:
- Antidepressants: Tricyclic antidepressants (TCAs) and Serotonin-Noradrenaline Reuptake Inhibitors (SNRIs)
- Anticonvulsants: Pregabalin and Gabapentin (act on calcium channels)
Examples of First-Line Treatments
| Medication Type | Example Medications | How They Work |
|---|---|---|
| Tricyclic Antidepressants | Amitriptyline, Nortriptyline | Affect neurotransmitters to reduce pain signals. |
| SNRIs | Duloxetine, Venlafaxine | Affect neurotransmitters to reduce pain signals. |
| Calcium Channel Blockers | Pregabalin, Gabapentin | Calm overactive nerve signals by affecting calcium channels. |
Second and Third-Line Treatments
It's important to know that if first-line treatments aren't effective, other options exist.
- Second-line drugs:
- Topical lidocaine
- Third-line drugs:
- Opioids
These are typically considered after first-line options have been explored due to factors like side effects or risk of dependence.
