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What are CTE symptoms?

Published in Neurology 3 mins read

CTE symptoms are varied and complex, primarily affecting mood, behavior, and cognition, often appearing years after repetitive head trauma. These symptoms can be debilitating and progressively worsen over time.

Common Symptoms of CTE

The symptoms of Chronic Traumatic Encephalopathy (CTE) can be broadly categorized as:

  • Cognitive Impairment:

    • Memory loss: Difficulty remembering recent events or learning new information.
    • Confusion: Feeling disoriented or having difficulty thinking clearly.
    • Impaired Judgment: Making poor decisions or exhibiting a lack of common sense.
  • Behavioral and Mood Disturbances:

    • Impulse Control Problems: Acting without thinking, leading to inappropriate or risky behavior.
    • Aggression: Increased irritability, anger, and potentially violent outbursts.
    • Depression: Persistent feelings of sadness, hopelessness, and loss of interest in activities.
    • Anxiety: Excessive worry, nervousness, and fear.
    • Suicidality: Thoughts of suicide or attempts to end one's life.
  • Motor Symptoms:

    • Parkinsonism: Symptoms similar to Parkinson's disease, such as tremors, rigidity, slow movement, and postural instability.
    • Dysarthria: Difficulty speaking clearly.
    • Dysphagia: Difficulty swallowing.
  • Progressive Dementia: Over time, CTE can lead to progressive dementia, characterized by a significant decline in cognitive function, affecting all aspects of daily life.

Two Clinical Presentations of CTE: Behavioral/Mood vs. Cognitive

Researchers have observed two main presentations of CTE symptoms:

  1. Behavioral/Mood Presentation: This involves primarily behavioral and mood disturbances early in the disease course, such as impulsivity, aggression, depression, and anxiety.
  2. Cognitive Presentation: This presentation involves primarily cognitive impairment, such as memory loss and executive dysfunction, early in the disease course.

Important Considerations

  • Onset: Symptoms often begin years or even decades after the last brain trauma or the end of active athletic involvement.
  • Variability: The severity and presentation of symptoms can vary greatly from person to person.
  • Diagnosis: Definitive diagnosis of CTE can only be made through autopsy. Clinical diagnosis is based on a patient's history of repetitive head trauma and the presence of characteristic symptoms.
  • Other Conditions: It's important to rule out other conditions that can cause similar symptoms, such as Alzheimer's disease, Parkinson's disease, and other forms of dementia.

In summary, CTE presents with a complex range of symptoms affecting cognition, behavior, mood, and motor function, leading to progressive decline and significantly impacting the individual's quality of life. Early recognition and management are crucial.

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