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What Causes CSF Headache?

Published in Neurology 3 mins read

A CSF headache, often due to low cerebrospinal fluid pressure, is caused by an internal spinal fluid leak.

Low-pressure headaches, specifically those stemming from cerebrospinal fluid (CSF) leaks, occur when the delicate balance of fluid surrounding the brain and spinal cord is disrupted. The brain is effectively cushioned within a sac filled with CSF, which extends from the skull down into the spine. When a leak occurs, the pressure within this system decreases, leading to a variety of symptoms, the most prominent of which is a headache.

Understanding CSF Leaks

Here's a breakdown of the key elements:

  • Cerebrospinal Fluid (CSF): This clear fluid protects the brain and spinal cord from injury, removes waste products, and delivers nutrients.
  • The "Bag" Analogy: Imagine the brain and spinal cord sitting inside a fluid-filled bag. This "bag" is formed by the meninges, the membranes that surround the central nervous system.
  • The Leak: A tear or hole in the meninges allows CSF to escape, reducing the pressure within the system.

Consequences of Low CSF Pressure

The decrease in CSF pressure has several effects:

  • Brain Sag: The brain essentially sags within the skull due to the reduced buoyancy normally provided by the CSF. This sagging can put traction on pain-sensitive structures.
  • Headache: This is the most common symptom. It's often positional, meaning it worsens when sitting or standing and improves when lying down.
  • Other Symptoms: Besides headache, low CSF pressure can also cause nausea, vomiting, neck stiffness, dizziness, tinnitus (ringing in the ears), vision changes, and cognitive difficulties.

Causes of CSF Leaks

While the underlying cause is always a leak, the reason for that leak can vary:

  • Spontaneous Leaks: Sometimes, a leak occurs without any obvious trauma or medical procedure. This is called a spontaneous CSF leak. Connective tissue disorders or weakened areas of the meninges are often suspected.
  • Traumatic Leaks: Head injuries or spinal trauma can tear the meninges, leading to a leak.
  • Iatrogenic Leaks: These leaks are caused by medical procedures, such as lumbar punctures (spinal taps), epidural injections, or spinal surgery.

Diagnosis and Treatment

Diagnosing a CSF leak can involve:

  • MRI of the brain and spine: To look for signs of low CSF pressure and potential leak sites.
  • CT myelography: Injecting dye into the spinal fluid and then performing a CT scan to identify the leak.
  • Cisternography: A nuclear medicine scan to track the flow of CSF.

Treatment options range from conservative measures like bed rest and increased fluid intake to more invasive procedures like epidural blood patches (injecting the patient's blood into the epidural space to seal the leak) or surgery to repair the meningeal tear.

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