The term "forgotten organ" is applied to several different organs, depending on context. There is no single answer. Several organs have been described as "forgotten" due to a relative lack of research compared to others or because of their often-overlooked importance.
The Microbiome: Often Called the Forgotten Organ
The most frequently cited "forgotten organ" is the microbiome. This refers to the trillions of microorganisms (bacteria, fungi, and viruses) living in and on our bodies. [Source: Examining the Forgotten Organ, KUCancerCenter; Gut Microbiota: From the Forgotten Organ to a Potential Key Player..., PubMed] This complex ecosystem plays a crucial role in various bodily functions, including digestion, immunity, and even mental health. Each person's microbiome is unique, shaped by genetics and early life experiences. [Source: Examining the Forgotten Organ, KUCancerCenter] The collective metabolic activity of the microbiome is so significant it's considered a virtual organ within an organ. [Source: The gut flora as a forgotten organ, PMC] Recent research highlights its importance, showing how it interacts with diseases like Alzheimer's by affecting neuroinflammation and metabolic balance. [Source: Gut Microbiota: From the Forgotten Organ to a Potential Key Player..., PubMed; Gut Microbiota: From the Forgotten Organ to a Potential Key Player..., DOI] It is increasingly recognized as a key player in overall health, and no longer simply a forgotten organ. [Source: Gut Microbiota: No Longer the Forgotten Organ, Annals of Nutrition]
Other Organs Described as "Forgotten":
Besides the microbiome, other organs have been called the "forgotten organ" in specific contexts:
- The Liver: The liver is vital for detoxification and numerous metabolic processes, yet often receives less attention than the heart or brain. [Source: Liver: The Forgotten Organ, VA News]
- The Placenta: Essential for fetal development, the placenta mediates nutrient and waste exchange between mother and fetus. Its complexity and critical role are sometimes overlooked. [Source: Placenta: The Forgotten Organ | Annual Reviews; Placenta: the forgotten organ, PubMed]
- The Avian Liver: In poultry, the avian liver's susceptibility to fatty liver disease during high production periods is sometimes overlooked. [Source: Avian Liver: The Forgotten Organ, MDPI]
The use of "forgotten organ" highlights the importance of continued research and understanding of all organ systems within the body, regardless of the current level of public or scientific awareness.
