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What are the top 3 pain relief?

Published in Pain Relief 3 mins read

The top 3 over-the-counter (OTC) pain relievers are ibuprofen, naproxen, and aspirin.

Understanding Common OTC Pain Relievers

When seeking relief from pain, many people turn to over-the-counter (OTC) medications. Here's a breakdown of three commonly used options, as identified in the reference:

1. Ibuprofen

  • Brand Names: Often sold under names like Advil and Motrin.
  • Mechanism: Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing hormones that cause pain and inflammation in the body.
  • Uses: Effective for headaches, muscle aches, menstrual cramps, and reducing fever.

2. Naproxen

  • Brand Name: Commonly known as Aleve.
  • Mechanism: Similar to ibuprofen, naproxen is an NSAID that decreases inflammation and pain.
  • Uses: Effective for a variety of pain conditions, including arthritis, muscle strains, and menstrual pain. It is often favored for providing longer-lasting relief compared to ibuprofen.

3. Aspirin

  • Brand Names: Found in stand-alone products and combination products like Alka-Seltzer.
  • Mechanism: Aspirin is another NSAID that works by reducing pain, fever, and inflammation. It is also known for its antiplatelet properties, making it useful for reducing the risk of heart attack and stroke under the guidance of a doctor.
  • Uses: Primarily used for pain relief, reducing fever, and (at low doses) preventing blood clots.

Other Over-the-Counter Pain Relief Options

While ibuprofen, naproxen, and aspirin are top choices, other OTC options are available:

  • Acetaminophen (Tylenol): Effective for pain relief and fever reduction but does not have anti-inflammatory properties like NSAIDs.
  • Diclofenac 1% gel (Voltaren Arthritis Pain): A topical NSAID that provides localized relief for joint pain and arthritis.
  • Alka-Seltzer: Combines aspirin with citric acid and sodium bicarbonate, often used for relief from heartburn and upset stomach in addition to pain relief.


Pain Reliever Brand Names Type Primary Use
Ibuprofen Advil, Motrin NSAID Pain relief, fever, inflammation
Naproxen Aleve NSAID Pain relief, inflammation
Aspirin Alka-Seltzer (combination) NSAID Pain relief, fever, blood thinning
Acetaminophen Tylenol Analgesic Pain relief, fever
Diclofenac 1% gel Voltaren Arthritis Pain Topical NSAID Localized joint pain


It is important to consult with a healthcare provider or pharmacist before taking any medication to ensure that it is appropriate for your specific condition.

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