The two examples of pathway inhibitors discussed here, specifically targeting the Hedgehog signaling pathway, are vismodegib and sonidegib.
Vismodegib and Sonidegib: SMO Inhibitors
Both vismodegib and sonidegib are inhibitors of Smoothened (SMO), a protein crucial in the Hedgehog signaling pathway. This pathway plays a significant role in cell growth and development. When the pathway is abnormally activated, it can lead to certain cancers, such as basal cell carcinoma.
Clinical Application
- Vismodegib and sonidegib are used for the treatment of basal cell carcinoma, a common type of skin cancer.
Target
- Both drugs work by specifically targeting and inhibiting Smoothened (SMO), thus disrupting the signaling cascade and inhibiting tumor growth.
| Inhibitor | Target | Clinical Use |
|---|---|---|
| Vismodegib | Smoothened(SMO) | Treatment of Basal Cell Carcinoma |
| Sonidegib | Smoothened(SMO) | Treatment of Basal Cell Carcinoma |
