Peroxisomes divide through a carefully orchestrated three-step process involving elongation, constriction, and fission.
The process of peroxisome division is essential for maintaining a healthy population of these organelles within cells. This process can be broken down into distinct stages, each involving specific proteins.
The Steps of Peroxisome Division
Here's a breakdown of the steps:
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Peroxisome Elongation: This initial phase sees the peroxisome growing in size. According to the provided reference, Pex11 proteins mediate the elongation step. Think of Pex11 proteins as the architects of peroxisome growth, facilitating the expansion of the organelle's membrane.
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Membrane Constriction: Following elongation, the peroxisome membrane begins to constrict. This is the "pinching" stage, where the elongated peroxisome starts to narrow in the middle, preparing for separation.
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Peroxisome Fission: This is the final stage where the peroxisome divides into two daughter peroxisomes. The provided reference states that dynamin-related proteins execute the final fission. Dynamin-related proteins act like molecular scissors, cutting the peroxisome into two separate entities.
In summary, the division of peroxisomes is a dynamic and regulated process ensuring that cells maintain the appropriate number of these vital organelles.
