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Do peroxisomes produce ATP?

Published in Peroxisome Metabolism 2 mins read

Peroxisomes produce ATP, but not directly through the typical pathways like oxidative phosphorylation. While they don't have their own ATP-generating systems, the β-oxidation process within peroxisomes can indirectly lead to the generation of ATP.

Here's a breakdown:

  • Peroxisomal β-Oxidation: Peroxisomes and mitochondria both perform β-oxidation, but they have different enzymes and substrate specificities.
  • ATP Generation in Mitochondria: According to the reference, mitochondrial β-oxidation can generate 2 ATP molecules per cleavage cycle. However, the provided context does not explicitly state that peroxisomes themselves generate ATP directly.
  • Indirect ATP Production: The products of peroxisomal β-oxidation (e.g., acetyl-CoA) are often shuttled to mitochondria, where they can be further processed through the citric acid cycle and oxidative phosphorylation to ultimately generate ATP.
Organelle β-Oxidation Direct ATP Production
Peroxisomes Yes No, but contributes substrates
Mitochondria Yes Yes (2 ATP/cycle)

In summary, peroxisomes don't generate ATP through the same mechanisms as mitochondria. Instead, they contribute to overall cellular ATP production by processing fatty acids into forms usable by mitochondria. The ultimate ATP production occurs within the mitochondria from the peroxisome-derived substrates.

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