The primary metabolite of DDT (dichlorodiphenyltrichloroethane) is DDE (dichlorodiphenyldichloroethylene).
DDT and its Metabolite, DDE
DDT is an organochlorine pesticide that was widely used but has since been banned in North America since 1972 due to environmental and health concerns. One of its major breakdown products, or metabolites, is DDE.
DDE: The Active Metabolite
- DDE is formed when DDT degrades in the environment or within organisms.
- DDE is the most prevalent and stable metabolite of DDT and is found ubiquitously in various tissues of humans and wildlife around the globe.
- DDE acts as an androgen receptor antagonist, meaning it can interfere with the normal function of androgen hormones in the body. This interference can cause various health issues.
Key Points about DDT Metabolism
- DDT is metabolized to DDE via a dehydrochlorination process.
- DDE is more persistent in the environment than DDT and tends to bioaccumulate in living organisms.
- The presence of DDE in biological samples serves as an indicator of past exposure to DDT.
| Metabolite | Description | Environmental Impact | Biological Effects |
|---|---|---|---|
| DDE | Primary metabolite of DDT | More persistent in the environment; tends to bioaccumulate. | Acts as an androgen receptor antagonist; found in human tissues worldwide. |
Therefore, the most significant metabolite of DDT is DDE, a substance of toxicological and environmental concern.
