In the pharmaceutical industry, WIP typically stands for Wash-in-Place.
Understanding Wash-in-Place (WIP)
While the terms Clean-in-Place (CIP) and Wash-in-Place (WIP) are often used interchangeably, particularly since there is no specific GMP or legislative distinction, there's a generally accepted understanding within the industry that differentiates them based on the level of automation.
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Clean-in-Place (CIP): Refers to a fully automated cleaning sequence. This process involves cleaning equipment or systems without dismantling them. CIP systems typically utilize automated controls to circulate cleaning solutions, rinse water, and sanitizing agents through the equipment. No manual intervention is required.
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Wash-in-Place (WIP): Involves a cleaning process with some level of manual intervention. This means that while some steps may be automated, operators might need to manually apply cleaning solutions, brush certain areas, or perform other hands-on tasks.
Key Differences Summarized
| Feature | Clean-in-Place (CIP) | Wash-in-Place (WIP) |
|---|---|---|
| Automation Level | Fully Automated | Partially Automated |
| Manual Intervention | None | Some |
| Equipment | Typically large, complex systems | Smaller, simpler systems or components within a larger system |
Practical Implications
The choice between CIP and WIP depends on factors such as the equipment's complexity, the level of cleanliness required, validation requirements, and cost considerations. WIP is often chosen for equipment that is difficult or impractical to automate completely.
Examples of WIP
- Manually applying cleaning agents to the interior of a small mixing tank after a partial automated rinse.
- Manually cleaning removable parts of a filling machine.
