No, aspirin does not block the initial aggregation induced by ADP.
According to the provided reference, aspirin treatment does not affect the primary wave of ADP-induced platelet aggregation. This means that while aspirin has antiplatelet effects, it doesn't directly block the initial response of platelets to ADP. Aspirin primarily works by inhibiting the production of thromboxane A2, which amplifies platelet aggregation.
- Aspirin's Mechanism: Aspirin inhibits cyclooxygenase (COX), preventing the formation of thromboxane A2.
- ADP's Role: ADP binds to platelet receptors, triggering activation and aggregation.
- Reference Confirmation: "The primary wave of ADP-induced aggregation was unaffected by aspirin treatment." This statement directly supports the conclusion that aspirin does not block the initial ADP-mediated aggregation.
