Adenosine deaminase (ADA) in pleural fluid is a crucial marker, especially for identifying tuberculous pleural effusion (TBPE).
Understanding ADA
- Definition: Adenosine deaminase (ADA) is an enzyme found in the body. In the context of pleural fluid, its levels can indicate certain conditions.
- Significance: Elevated levels of ADA are strongly associated with tuberculosis (TB).
ADA as an Indicator of TBPE
According to the provided reference:
- Effective Indicator: ADA is an effective indicator of TBPE.
- Cut-off Value: A routine cut-off value for pleural fluid ADA is 40 U/L.
- Likelihood of TB: The higher the level of ADA, the greater the likelihood that an individual has TB.
Key Points on ADA in Pleural Fluid
| Aspect | Details |
|---|---|
| Enzyme | Adenosine deaminase |
| Purpose | Indicator for TBPE |
| Cut-off Value | 40 U/L (routine) |
| Interpretation | Higher ADA levels indicate higher probability of TB |
| Clinical Relevance | Aids in diagnosing tuberculous pleural effusion |
Practical Implications
- Diagnosis: Measuring ADA levels helps in diagnosing TBPE, guiding appropriate treatment decisions.
- Clinical Context: While elevated ADA strongly suggests TB, other conditions can sometimes cause elevated levels, so clinical context is important.
- Routine Test: ADA measurement is a routine test when evaluating pleural effusions, especially when TB is suspected.
