A normal total bile acid level in pregnancy is generally considered to be up to 11.0 μmol/L in late gestation.
While bile acid levels are slightly higher in pregnant women compared to non-pregnant women, levels exceeding 11.0 μmol/L may indicate a potential issue, such as intrahepatic cholestasis of pregnancy (ICP).
Here's a breakdown:
- Non-pregnant women: Average bile acid levels are around 5.7 ± 0.4 μmol/L.
- Pregnant women: Average bile acid levels are slightly elevated, around 6.6 ± 0.3 μmol/L.
- Normal range in late gestation: Up to 11.0 μmol/L is often considered within the normal range.
- ICP Diagnostic Threshold: A level greater than 11 μmol/L is notable and usually diagnostic for ICP.
It's crucial to consult with a healthcare professional for proper interpretation of bile acid levels during pregnancy and to rule out any underlying conditions. An isolated bile acid measurement may be misleading. Clinical findings, in addition to laboratory findings, are critical to the diagnosis of ICP.
