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How is Protein Digested?

Published in Protein Digestion 2 mins read

Protein digestion is the process of breaking down complex protein molecules into smaller peptides and, ultimately, individual amino acids, which the body can then absorb and use.

Here's a breakdown of the protein digestion process:

1. Stomach:

  • Gastric Juice: The stomach secretes gastric juice containing hydrochloric acid (HCl) and pepsinogen.
  • HCl Activation: HCl converts inactive pepsinogen into its active form, pepsin.
  • Pepsin's Role: Pepsin is an enzyme that begins the breakdown of proteins (proteolysis) by cleaving the peptide bonds, breaking the long protein chains into smaller peptides.
  • Churning Action: The stomach's muscular contractions further aid in breaking down food and mixing it with gastric juices.

2. Small Intestine:

  • Pancreatic Enzymes: Partially digested proteins (peptides) move into the small intestine, where enzymes secreted by the pancreas further break them down. Key pancreatic enzymes include:
    • Trypsin: Breaks down proteins into smaller peptides.
    • Chymotrypsin: Similar to trypsin, breaks down proteins into smaller peptides.
    • Carboxypeptidase: Breaks down peptides by removing amino acids from the carboxyl (COOH) end of the peptide chain.
  • Intestinal Enzymes: The small intestine's lining also secretes enzymes, such as peptidases, that break down the remaining small peptides into individual amino acids.

3. Absorption:

  • Amino Acid Uptake: The individual amino acids are then absorbed through the intestinal lining and enter the bloodstream.
  • Transportation: The bloodstream transports the amino acids to various parts of the body where they are used for protein synthesis, enzyme production, hormone creation, and other essential functions.

Summary Table:

Organ Secretions/Enzymes Action
Stomach HCl, Pepsinogen HCl activates pepsin; pepsin begins protein breakdown into peptides.
Small Intestine Trypsin, Chymotrypsin, Carboxypeptidase, Peptidases Further breakdown of peptides into amino acids.

In essence, protein digestion involves enzymatic hydrolysis in the stomach and small intestine, resulting in the breakdown of proteins into absorbable amino acids.

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